Huh? Do you have any actual examples of such studies? I don't think you understand how IRB actually works.
In actual heart medicine studies the control arm is typically treated with the current standard of care, not a placebo. So it seems pretty clear that you don't have any actual knowledge or experience in this area.
In actual heart medicine studies the control arm is typically treated with the current standard of care, not a placebo. So it seems pretty clear that you don't have any actual knowledge or experience in this area.